Home
Back
Cockcroft-Gault Equation:
| From: | To: |
The Cockcroft-Gault equation estimates creatinine clearance (CrCl) from serum creatinine, age, weight, and gender. It is widely used for drug dosing adjustments in patients with renal impairment and for assessing kidney function.
The calculator uses the Cockcroft-Gault equation:
Where:
Explanation: The equation estimates the rate at which creatinine is cleared from the blood by the kidneys, providing an approximation of glomerular filtration rate.
Details: Creatinine clearance is essential for determining appropriate drug dosages for medications that are renally excreted, assessing kidney function, and monitoring patients with chronic kidney disease.
Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. All values must be valid (age between 1-120, weight > 0, creatinine > 0).
Q1: Why use Cockcroft-Gault equation?
A: It is one of the most widely validated equations for estimating creatinine clearance and is commonly used for drug dosing adjustments in clinical practice.
Q2: What are normal CrCl values?
A: Normal CrCl is approximately 95-125 mL/min for young adults, decreasing with age. Values below 60 mL/min indicate renal impairment.
Q3: When should creatinine clearance be measured?
A: When prescribing drugs with narrow therapeutic windows that are renally excreted, or when assessing kidney function in patients at risk of renal impairment.
Q4: Are there limitations to this equation?
A: Less accurate in elderly, obese, or malnourished patients, and in those with rapidly changing kidney function or unstable creatinine levels.
Q5: Should ideal body weight be used?
A: For obese patients, some guidelines recommend using ideal body weight rather than actual body weight for more accurate estimation.