Creatinine Clearance Calculator EPI

CKD-EPI Equation:

\[ CrCl = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{Age} \times (1.018 \text{ if female}) \]

Creatinine Clearance (CrCl):

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What is the CKD-EPI Creatinine Clearance Equation?

The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation estimates creatinine clearance from serum creatinine, age, and sex. It provides a more accurate assessment of kidney function than older equations, especially at higher clearance levels.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

\[ CrCl = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{Age} \times (1.018 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.329 (female) or -0.411 (male)
\( Age \) — Age in years
1.018 — Female multiplier

Explanation: The equation accounts for non-linear relationship between creatinine and clearance rate, with different coefficients for different demographic groups.

3. Importance of Creatinine Clearance Calculation

Details: Accurate creatinine clearance estimation is crucial for assessing kidney function, determining medication dosing, and evaluating overall renal health.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: What is creatinine clearance?
A: Creatinine clearance measures how well the kidneys filter creatinine from the blood, providing an estimate of glomerular filtration rate.

Q2: What are normal creatinine clearance values?
A: Normal values typically range from 90-120 mL/min for adults, though values may vary based on age, sex, and body size.

Q3: How does this differ from eGFR?
A: Creatinine clearance specifically measures the rate at which creatinine is cleared, while eGFR estimates overall glomerular filtration rate.

Q4: When is creatinine clearance testing indicated?
A: It's used for drug dosing adjustments, monitoring kidney function in chronic disease, and evaluating renal impairment.

Q5: Are there limitations to this calculation?
A: Results may be less accurate in elderly patients, those with extreme body weights, or individuals with rapidly changing kidney function.