Corrected Creatinine Clearance Calculator

Corrected Creatinine Clearance Formula:

\[ CrCl_{corrected} = CrCl \times \left( \frac{BSA}{1.73} \right) \]

Corrected Creatinine Clearance:

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What is Corrected Creatinine Clearance?

Corrected creatinine clearance normalizes renal function to a standard body surface area of 1.73 m², allowing for better comparison between individuals of different sizes and more accurate assessment of kidney function.

2. How Does the Calculator Work?

The calculator uses the corrected creatinine clearance formula:

\[ CrCl_{corrected} = CrCl \times \left( \frac{BSA}{1.73} \right) \]

Where:

\( CrCl \) — Measured creatinine clearance (mL/min)
\( BSA \) — Body surface area (m²)
\( 1.73 \) — Standard reference body surface area

Explanation: This correction adjusts the measured creatinine clearance to account for differences in body size, providing a standardized measure of renal function.

3. Importance of BSA Correction

Details: Body surface area correction is essential because kidney function is proportional to metabolic rate, which correlates better with BSA than with body weight. This normalization allows for accurate comparison of renal function across different body sizes.

4. Using the Calculator

Tips: Enter measured creatinine clearance in mL/min and body surface area in m². Both values must be positive numbers. BSA can be calculated using various formulas (Mosteller, Du Bois, etc.).

5. Frequently Asked Questions (FAQ)

Q1: Why correct creatinine clearance for BSA?
A: Correction to standard BSA allows comparison of renal function between individuals of different sizes and provides a more accurate assessment of true kidney function.

Q2: What is the standard BSA value of 1.73 m²?
A: 1.73 m² represents the average body surface area of a 70 kg adult male and has been established as the reference standard for renal function normalization.

Q3: How is BSA typically calculated?
A: BSA can be calculated using formulas like Mosteller (√[height(cm)×weight(kg)/3600]) or Du Bois (0.007184×height(cm)^0.725×weight(kg)^0.425).

Q4: When is corrected creatinine clearance used?
A: It's used in clinical practice for drug dosing adjustments, assessing renal function in clinical trials, and comparing kidney function across different patient populations.

Q5: Are there limitations to BSA correction?
A: While useful for most adults, BSA correction may be less accurate in extremes of body composition (severe obesity, cachexia) and in pediatric populations where different approaches may be needed.